Adding new stem cell tools to the Parkinson’s disease toolbox

Understanding a complicated neurodegenerative disorder like Parkinson’s disease (PD) is no easy task. While there are known genetic risk factors that cause PD, only about 10 percent of cases are linked to a genetic cause. The majority of patients suffer from the sporadic form of PD, where the causes are unknown but thought to be a combination of environmental, lifestyle and genetic factors.

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Toxicology in the 21st Century, An Interview with Dr. Tice and Dr. Paules

The seminar given by Dr. Tice and Dr. Paules focused on the “Toxicology in the 21st Century Partnership” (or “Tox21”) . Launched in 2007, Tox21 is a U.S. multiagency collaborative effort involving the National Institute of Environmental Health Sciences (NIEHS)/National Toxicology Program (NTP), the National Center for Advancing Translational Sciences (NCATS), the Environmental Protection Agency’s (EPA’s) National Center for Computational Toxicology, and the Food and Drug Administration (FDA). Tox21 was formed in response to the fact that are tens of thousands of chemicals in our daily life that we have minimal understanding of potential toxic effects on humans. The goal of Tox21 is to develop more efficient and less time-consuming approaches to predict how chemicals may affect human health, leading to better regulations and treatments in cases of exposure.

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Reproductive Aging: An Interview with Dr. Coleen Murphy

Dr. Murphy’s lab is focused on a few main areas of research that all focus on quality of life with age, using C. elegans to model human aging. 1) How is reproductive span regulated, and how does that relate to the regulation of longevity? 2) How can cognitive decline be slowed? 3) How does the insulin/IGF-1 Signaling/FOXO pathway and its interactions regulate longevity, reproductive span, and cognitive decline? Dr. Murphy’s seminar focused on reproductive span and how this relates to lifespan.

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Mitochondria, Senescence, and Aging: Connecting the Dots

Today, we’re including a special perspective written by Buck postdoc Chris Wiley on his recent publication in Cell Metabolism (“Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype.” Cell Metab. 2016 Feb 9;23(2):303-14.) which covers a unique and unexpected connection between mitochondria and the aging process. The full publication can be found here.

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LIVE Debate on “Lifespans are Long Enough”

In the midst of all the recent debates we have special debate today, discussing if “Lifespans are Long Enough”. The Buck Institute’s CEO Dr. Brian Kennedy is participating in this debate being broadcast LIVE online! Today (Feb 3rd, 6:45pm EST and 3:45pm PST) Live Stream... read more

Interview with Dr. Xianmin Zeng: Stem Cell Treatment for Parkinson’s Disease

After establishing her laboratory, Dr. Zeng was awarded a prestigious grant from the California Institute for Regenerative Medicine to spearhead the development of a stem cell-based treatment for Parkinson’s disease. After years of dedicated work creating the cell lines and collaborating on a delivery system the Zeng laboratory and their industry collaborators have developed a stem cell based treatment that is ready for human clinical trials.

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Life Is Too Sweet To Be Short

This article by Dr. Jyotiska Chaudhuri was selected as the Third Place winner to our 2015 SAGE blog contest! He discusses why the foods we enjoy the most often bad for us, and why they might influence our health and longevity.

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Hungry Neurons: An Interview With Dr. Zachary Knight on How We Respond to Food.

Dr. Knight’s lab studies neural circuits in the mouse that control feeding and other motivated behaviors central to survival. The labs goal is to understand how these circuits are able to sense the needs of the body and then generate the specific behavioral responses that restore homeostasis. During the seminar, Dr. Knight described how the brain’s “hunger circuit” governs eating.

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