Author: Jyotiska Chaudhuri

Caenorhabditis elegans: a model organism revisited

It feels like yesterday that I was sitting in the Tom and Lula Gooch auditorium at UT Southwestern listening to a mesmerizing speech on ‘Mapping the human genome’. This was three years ago and the speaker was the 2002 Nobel Prize-winning scientist Dr. Sydney Brenner. His introduction and establishment of the free-living nematode Caenorhabditis elegans as a model organism for genetic and molecular studies opened new horizons in scientific research. It took nearly three decades since its inception for scientists to sequence the first complete animal genome in 1998. It was C. elegans. As part of the Buck’s model organism seminar series organized by the Post-Doctoral Association, Dr. Kathleen (Katie) Dumas described how scientists are using C. elegans to understand fundamental processes of aging in humans. Katie did her PhD at University of Michigan, Ann Arbor with Dr. Patrick Hu, who is renowned for his research in C. elegans. She is currently continuing her postdoctoral research on aging in C. elegans in Dr. Gordon Lithgow’s lab at Buck Institute. Katie delivered a fantastic presentation and succinctly outlined to the audience the advantages of using the worm as a genetic model. She began with a background on basic worm morphology and developmental plasticity in different environmental conditions. She then navigated through the intricacies of using worms as a genetic tool. This ranged from using both forward and reverse genetics in...

Read More

Postdocs at the Buck Institute Launch seminar series on model organisms

Model systems are used extensively by scientists to answer a myriad of questions related to subjects ranging from development to complex diseases. The use of model systems (such as yeast, flies, worms, and mice) as tools for fundamental research did not happen in a single day. It takes several years of experimental dissection to develop and establish a model system. However, many of us still strive to understand the suitability of a specific system to answer a specific question. Let’s say you want to do a drug screen for a specific disease. Should you choose a fly or a...

Read More
  • 1
  • 2

Follow SAGE