Author: Kenny Wilson

Geroscience Course: Cellular Senescence and Aging

The process of aging is accompanied by numerous degenerative phenotypes. Muscles and bone break down, brain cells die, and overall physical ability deteriorates. One exception to this common trend of age-related degeneration is cancer, which results from a population of cells that survive through uncontrollable and unregulated proliferation. If most tissue functions decline with age, how can one of deadliest age-related diseases (cancer) arise from cells that are too active? The work of Dr. Judy Campisi at the Buck Institute has found a potential link between these phenomena. Many age-related traits result from replicative senescence (also called cellular senescence...

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