Author: Karen Ring

Interview with Dr. Maitreya Dunham: Aneuploidy, Adaptation, and Aging

Dr. Maitreya Dunham is an Associate Professor in the Department of Genome Sciences at the University of Washington, Seattle. She was previously a Lewis-Sigler Fellow at Princeton University in the Lewis-Sigler Institute. Dr. Dunham is interested in understanding how aneuploidy (abnormal number of chromosomes) and DNA copy number variation (CNV) (abnormal or varying copy number of genes) can cause disease and aging-related phenotypes.

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SAGE Review: Hydrogen Sulfide Sheds Light on the Beneficial Effects of Dietary Restriction.

Dietary restriction (DR), also commonly known as caloric restriction, is a strategy to improve health and increase lifespan by limiting the number of calories you eat. When combined with a nutritional diet, DR extends lifespan in a variety of species including yeast, worms, flies, and mice. Currently the effects of DR on lifespan in humans are unknown, however health benefits have been reported in caloric restriction studies in rhesus monkeys. For more background on this subject, read our recent blog post on caloric restriction and aging and our interview with Brian M. Delaney, President of the CR Society International....

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SAGE Review: Identifying cancer risk factors in old blood.

By Karen Ring The risk of getting cancer increases as you age due to multiple somatic mutations (meaning that you acquire the mutation rather than are born with it) that build up in certain cell populations over time. Hematological cancers, also known as “blood cancers” or “liquid tumors”, affect the blood, bone marrow, and lymph nodes. Examples of hematological cancers include leukemia (abnormal white blood cells), lymphoma (abnormal lymphocytes), and myeloma (abnormal plasma cells). Diagnosing blood cancers is relatively easy. Doctors can take blood samples from sick patients (instead of conducting invasive tumor biopsies) and look for abnormal cancer...

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Buck Postdocs and Grad Students Represent at the Bay Area Aging Meeting.

There was an impressive turnout of Buck postdocs and graduate students at this years Bay Area Aging Meeting (BAAM) held at the Gladstone Institutes on December 10th, 2014. BAAM is a semiannual meeting sponsored by the Glenn Foundation for Medical Research whose goal is to stimulate the advancement of aging research, promote its application to human health, and connect scientists throughout the Bay Area to facilitate collaboration. The event was organized by faculty and featured research talks and posters by postdocs and graduate students from UC Berkeley, UC Davis, UC San Francisco, Stanford, Gladstone Institutes, and the Buck Institute....

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Weekly Sage: November 10th, 2014

Sirtuins are certainly important in aging. Sirtuins are proteins that regulate important cellular processes such as cellular metabolism, apoptosis, inflammation, stress resistance, genomic stability, and aging. There are five different groups of sirtuins all of which harbor varying enzymatic functions. Both Class I (SIRT1, 2, 3) and Class IV (SIRT6 and 7) sirtuins are protein deacetylases (enzymes that remove acetyl groups from lysine amino acids on proteins) and require the compound nicotinamide adenine dinucleotide (NAD+) to function. Sirtuin function is linked to caloric restriction and aging in yeast and other model organisms. Specifically, scientists found that caloric restriction increases...

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