Author: Team SAGE

New Publication: MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

Remi-Martin Laberge is a postdoc in Dr. Judy Campisi’s lab, and the first author of an exciting paper recently published in Nature Cell Biology titled “MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation.” Remi and his coauthors showed that the MTOR inhibitor rapamycin blocks the senescence-associated secretory phenotype (SASP) by inhibiting translation of IL-1α, which prevents senescent fibroblasts from promoting cancer tumor growth. SAGE sat down with Remi to discuss the main findings of this paper, and the implications that his research will have on the fields of aging and cancer. 1. How would you explain...

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Watch Dr. David Perlmutter and Dr. Dale Bredesen discuss the brain-gut-microbiome connection

Gut health has proven to be critical for healthy brain function. Learn how the gut microbiome influences the brain in this provocative YouTube video from last Thursday’s inspiring conversation between Dr. David Perlmutter and Buck Professor Dr. Dale Bredesen. Dr. Bredesen says Dr. Perlmutter’s new book, “Brain Maker: The Power of Gut Microbes to Heal and Protect Your Brain—for Life“, explains how nurturing gut health can enhance brain function. “Thanks in large part to a dramatic new understanding of the brain-gut-microbiome connection, there’s new hope for the treatment of autism to Alzheimer’s to multiple sclerosis. David Perlmutter is a...

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The effects of age and dietary restriction on the tissue-specific metabolome of Drosophila

We’re kicking off a new feature here at SAGE that focuses on recent publications from labs here at the Buck Institute. Our first paper is from SAGE’s own Matt Laye (postdoc in the Kapahi lab), whose publication “The effects of age and dietary restriction on the tissue-specific metabolome of Drosophila” was just published in the journal Aging Cell. We asked Matt 10 questions about this paper. 1. How would you explain the main findings from this paper to the lay audience or say your grandmother? We found that aging alters a large portion of all the metabolites in flies, and that dietary restriction could reverse the changes in these “aging” metabolites. 2. What’s the most significant finding from the paper? We had two significant findings.  First, dietary restriction reverses major changes to metabolites with aging (all of the metabolites of the fly). Second, dietary restriction increases the “connectiveness” of all the metabolites, while aging causes metabolite levels to be less connected to each other. 3. What were the technological or conceptual innovations from this study? Conceptually we used a type of analysis called “Differential Coexpression Analysis”, which is a fancy way of saying that we examined not only how many different metabolites there were, but how those metabolites were connected to each other and whether those relationships changed with age or dietary restriction.  Technologically, we used high resolution mass...

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Interview with Dr. Alicia Kowaltowski: How Diet Affects Energy Metabolism

By Rob O’Brien and Karen Ring Research Background Dr. Alicia Kowaltowski is a professor at the University of Sao Paulo’s Institute of Chemistry in Brazil. The focus of her research is the relationship between nutrition and metabolism in mice and rats in order to better understand how specific genes, hormones and metabolites respond to different patterns of food intake. This is an important area for multiple diseases associated with aging, including diabetes and obesity, and as we have reported in the past, alteration of food intake has important effects on the lifespan of worms, flies, mice and (in some...

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Weekly SAGE: October 27th, 2014

Stem Cell Therapies for Diseases of Aging: Long-Awaited Trials in the Eye. By, Rob O’Brien and Karen Ring. One general facet of aging is a loss of the body’s ability to robustly repair itself or regenerate lost tissue. Diseases such as Alzheimer’s, diabetes, and stroke are all associated with loss of particular tissues and cell types over time. While we have been able to treat some diseases using tissue or organ transplants, there are substantial limitations to the supply and utility of these donor tissues. Human embryonic stem cells (ESCs) isolated in the late 90’s and human induced pluripotent...

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