Cancer | SAGE

New Publication: MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by pro...

The Parkinsonian Brain: Cellular Senescence and Neurodegeneration

SAGE Review: Game-changing discoveries in cancer and neuroinflammation

October is Breast Cancer Awareness Month!

October is a time to remember all who have lost their lives to breast cancer, honor its survivors, and recognize the progress being made to cure it. Read about the focuses of some notable breast cancer researchers, including the Buck’s own Dr. Christopher Benz!

SAGE goes to the Movies: A scientific review of “Deadpool“ (2016)

We’re going to look at the science behind the movie “Deadpool”, and ask whether –and to what degree — there is any scientific basis for Deadpool’s superhuman abilities. Deadpool’s primary ability is hyper-regeneration. He is able to shrug off potentially lethal bodily injuries, to the point where he severs his own hand, and within a few days has regrown a new one. But how did he gain these abilities, and how realistic might they be?

Cutting Edge Genome Engineering: My Experience at the Third Annual Re-Writing Genomes Conference

Each year, UC Berkeley hosts a conference on genome engineering. SAGE writer and editor Barbara Bailus shares her experiences at the conference, including those focused on the CRISPR/Cas 9 genome editing system.

Geroscience Course: Cellular Senescence and Aging

The process of aging is accompanied by numerous degenerative phenotypes. Muscles and bone break...

New Publication: MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

Remi-Martin Laberge is a postdoc in Dr. Judy Campisi’s lab, and the first author of an...

The Parkinsonian Brain: Cellular Senescence and Neurodegeneration

Parkinson’s Disease (PD) is the second most common age-related neurological disorder in the US....

SAGE Review: Game-changing discoveries in cancer and neuroinflammation

It’s always exciting when major scientific discoveries change the way we view and understand human...

Dogs, Dwarfism and Aging: Lessons From IGF1

The really fun thing about discussing signaling networks (the inputs that let cells make decisions...

Interview With Dr. Karl Lenhard Rudolph: Mechanisms of Aging and Transformation of Stem Cells

Research Background Dr. Rudolph’s comes to us all the way from Jena, Germany. He is currently the Scientific Director of the Leibniz Institute for Age Research at the Fritz Lipman Institute. His research focuses on the molecular...

Aging Fundamentals: Cellular Senescence

Half a century ago, a scientist named Leonard Hayflick discovered that the number of times a normal, non-cancerous human cell can divide is limited. Beyond this point, Hayflick noted that cells would stop dividing and that there is a maximum number of times a cell can divide. This hypothetical maximum number of cell divisions came to be known as the “Hayflick Limit”, and the phenomenon itself is now known as cellular senescence.