Category: Metabolism

Fatty Liver Disease: Adjusting the focus

The liver is a complex organ that is easily influenced by diet and lifestyle. How does the Western diet, which consists heavily of fats and carbohydrates, affect diseases in the liver? Read more to find out what is known about Non-alcoholic fatty liver disease and other associated diseases!

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Life Is Too Sweet To Be Short

This article by Dr. Jyotiska Chaudhuri was selected as the Third Place winner to our 2015 SAGE blog contest! He discusses why the foods we enjoy the most often bad for us, and why they might influence our health and longevity.

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Interview with Dr. Blake Rasmussen: The Role of mTORC1 Signaling in Human Sarcopenia

I think the way we eat should be addressed. For instance, most individuals consume all of their daily protein at one, maybe two meals during the day. The problem is that only so much of that protein gets used, the rest then gets stored as fat. Usually the high protein meals are lunch and dinner, and dinner is often the meal with the least physical activity following it…we need a 30-30-30 plan.

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Interview with Dr. Pankaj Kapahi: How Diet Influences Aging and Age Related Diseases

One of the big picture ideas is questioning the universality of the aging process. Does aging occur the same way in diabetics, cancer patients and normal individuals? At the same time we are also trying to focus on a particular age-related diseases like diabetic complications, while also trying to achieve a deeper understanding in the invertebrate models and examine their relevance in mammalian models.

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Geroscience Course: Pharmacological manipulation of aging

The Lithgow lab at the Buck Institute focuses on discovering pharmacological interventions that can delay certain effects of aging or prevent them altogether. Interventions under investigation include synthetic compounds, natural products, and normal metabolites found in humans.

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New Publication: Muscle-specific 4E-BP1 signaling activation improves metabolic parameters during aging and obesity

Dr. Brian Kennedy’s lab at the Buck Institute recently came out with a publication in the Journal of Clinical Investigation titled, “Muscle-specific 4E-BP1 signaling activation improves metabolic parameters during aging and obesity”. This study elegantly shows how blocking mTOR activity specifically in the skeletal muscles of mice can protect against age and obesity-induced decline in metabolic function.

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